Civil protection is a system of organizing participants, operational forces and citizens for protecting and rescuing people, animals, material and cultural goods as well as the environment in major disasters and catastrophes and for eliminating the consequences of terrorism and war destruction. In the City of Zagreb, for the needs of performing all the tasks of the Civil Protection System, an emergency management office has been established, which will be mentioned during the final work. The office consists of the Civil Protection Headquarters of the City of Zagreb, which has recently become very well known to the citizens due to the Covida-19 pandemic. The office also consists of seventeen headquarters of the Civil Protection of city districts, specialist units of the Civil Protection for search and rescue from ruins, rescue and search units in floods, seventeen general purpose teams in city districts and technical and tactical support units which have more than eight hundred members. In this work, we will get acquainted with some general characteristics in the area of Zagreb concerning health care institutions, critical infrastructure facilities. We will also see which historical events were required for the work of the Civil Protection and how it was organized and how it operated at that time. At the end of the paper, we will analyze possible threats and risks in the city area and the effects in dangerous situations, such as the earthquake of March, 2020. We will also analyze the Civil Protection response system and response area.