This work deals with the psychosocial state of a person, its meaning, exposure, consequences, and measures and preventions for the protection of human well-being. The aim of the work is to explain what psychosocial risks are and how they affect people, as well as methods of measures and prevention of psychosocial risks. One of the most significant problems in the field of occupational safety faced by organizations around the world are psychosocial risks and stress at work. The negative impact of stress in organizations on all participants has a significant contribution to negative health and economic outcomes. Managing stress at work has benefits at all levels. Preserved health, subjective well-being and job satisfaction for managers, healthy, motivated, productive workers, improved overall efficiency in the organization, greater involvement of workers, and reduced health care and pension system costs in society and the national economy. The process of reducing and eliminating psychosocial risks consists of primary, secondary and tertiary prevention. Readiness for changes is one of the most important prerequisites for effective stress management at work. A healthy workplace creates a work environment that supports the health, safety and well-being of workers and contributes to increased productivity and organizational performance. At the end of the paper, the experimental part will be analyzed with the collected data from the own survey on psychosocial risks.