Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome, Scotopic Sensitivity Syndrome, and Visual Stress) is a perceptual processing disorder. It affects 14% of the general population in the world and is included in the so-called neurodiversity. It is not an optical problem but a problem with the brain’s ability to process visual information. Signs of Irlen syndrome are the most common: light sensitivity, reading problems, headaches, and migraines, attention and concentration problems, strain and fatigue, problems with depth perception and print, or environmental distortions. Science-based medicine does not recognize this disorder as an official diagnosis, but as a manifestation of several neurological disorders that fall under the neurodiversity, and they consider the diagnosis and treatment of syndromes pseudoscience. But regardless of the approach, this problem appears in practice. The stimulus for the manifestation of symptoms can come from the relationship between the color and intensity of the background and the content of the media, as well as from the influence of glare and the intensity and color of the lighting in the environment. Today, whether we are studying, reading the news, or performing our professional tasks at work, our sources of information are digital media based on graphical user interfaces and two-way communication. This means that today, to make life and work easier for people who suffer from this disorder, when designing the living and working environment, we must take into account both the parameters of the working environment and the accessibility elements of digital media. From a professional point of view, these factors should be carefully included in modern workplace risk assessments to obtain inclusive and universally designed workplaces.