Transformer stations are part of the power transmission system, and their task is to transform the voltage from a higher voltage level to a lower or vice versa. The need of modern society for electricity consumption is constantly growing, and consequently the risk of fires and explosions on electrical plants, installations and equipment is growing. Fire and explosive hazards can occur as a result of obsolescence of devices and equipment, loads, thunder and other weather disasters, mechanical damage to installations due to the presence of various rodents and the like. When designing the facility, a fire risk assessment is made, which further guidelines for firefighting and treatment protocols. Proper selection and installation of fire detection and extinguishing systems, with adequate construction and technological solutions for fire protection are the basis of safety in case of fire, and the task of the system is to localize and prevent its further spread in the shortest possible time. This paper provides an overview of fire and explosive hazards, potential failures and causes of fires and explosions as well as the specifics of the firefighting process at TS Dubovac 110/10/10 kV, as well as potential failures and improvements in the firefighting process at such facility. Particular emphasis in writing the paper is placed on the experience gained by the author of the work in the field of firefighting in high-voltage buildings. It is important to emphasize that firefighting at substations always includes cooperation and coordinated activity of fire brigades and the competent branch office of HEP, the Ministry of the Interior and members of the State Administration for Protection and Rescue. Cooperation is important for quick and efficient firefighting in such facilities, but also saving human lives, which is an integral part of almost every firefighting intervention. Cooperation is based on actions in accordance with applicable legal regulations and bylaws in the territory of the Republic of Croatia.